Low doses of 15d-PGJ2 induce osteoblast activity in a PPAR-gamma independent manner
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منابع مشابه
15-Deoxy-Δ12,14-Prostaglandin J2 Protects PC12 cells from LPS-Induced Cell Death Through Nrf2 pathway in PPAR-γ Dependent Manner
Introduction: The inflammatory response requires a coordinated integration of various signaling pathway including cyclooxygenase (COX). COX catalyzes the formation of prostaglandins from arachidonic acid. Among prostaglandins, 15-Deoxy-D12, 14-prostaglandin J2 (15d-PGJ2), an endogenous ligand of Peroxisome proliferator-activated receptor-gamma (PPAR-γ), has been demonstrated to have anti-inflam...
متن کامل15-Deoxy-Δ12,14-ProstaglandinJ2 Regulates Dedifferentiation through Peroxisome Proliferator-Activated Receptor-γ-Dependent Pathway but Not COX-2 Expression in Articular Chondrocytes
Peroxisome proliferator-activated receptors-gamma (PPAR-gamma) is critical for phenotype determination at early differentiation stages of mesenchymal cells, whereas its physiological role is unclear. Therefore, we investigated the role of 15-deoxy-Delta(12,14)-prostaglandinJ2 (15d-PGJ2), the natural receptor ligand for PPAR-gamma, on dedifferentiation and inflammatory responses, such as COX-2 e...
متن کاملhepatocyte growth factor is a downstream effector that mediates the antifibrotic action of peroxisome proliferator-activated receptor-gamma agonists.
Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) is a ligand-dependent transcription factor that plays an important role in the regulation of insulin sensitivity and lipid metabolism. Evidence shows that PPAR-gamma agonists also ameliorate renal fibrotic lesions in both diabetic nephropathy and nondiabetic chronic kidney disease. However, little is known about the mechanism underly...
متن کامل15-deoxy-δ12,14-prostaglandin j2 protects pc12 cells from lps-induced cell death through nrf2 pathway in ppar-γ dependent manner
introduction: the inflammatory response requires a coordinated integration of various signaling pathway including cyclooxygenase (cox). cox catalyzes the formation of prostaglandins from arachidonic acid. among prostaglandins, 15-deoxy-d12, 14-prostaglandin j2 (15d-pgj2), an endogenous ligand of peroxisome proliferator-activated receptor-gamma (ppar-γ), has been demonstrated to have anti-inflam...
متن کاملBiphasic Effects of 15-Deoxy- -Prostaglandin J2 on Glutathione Induction and Apoptosis in Human Endothelial Cells
The lipid products derived from the cyclooxygenase pathway can have diverse and often contrasting effects on vascular cell function. Cyclopentenone prostaglandins (cyPGs), such as 15-deoxy-prostaglandin-J2 (15d-PGJ2), a peroxisome proliferator–activated receptor(PPAR ) agonist, have been reported to cause endothelial cell apoptosis, yet in other cell types, cyPGs induce cytoprotective mediators...
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ژورنال
عنوان ژورنال: International Immunopharmacology
سال: 2013
ISSN: 1567-5769
DOI: 10.1016/j.intimp.2013.03.035